Cobalt (II)-catalyzed direct C3-selective C–H acyloxylation of indoles with tert-butyl peresters

Abstract

A Co(II)-catalyzed direct C3-selective C–H acyloxylation of indoles has been realized with tert-butyl peresters serving as both an acyloxy source and an oxidant. This reaction features highly C3 regioselectivity and good functional group tolerance, which provides a convenient and versatile approach to the construction of valuable 3-acyloxyindoles in moderate to excellent yields.

Graphical Abstract

Keywords:

• 3-Acyloxyindoles
• cobalt catalysis
• C–H acyloxylation
• C3-selective
• indoles
• tert-butyl peresters

Additional information

Funding

Financial support from the National Natural Science Foundation of China [Nos. 21562052 and 21462055], the Guizhou Provincial Department of Science and Technology [No. LH[2014]7547, and LH[2014]7554], 15851 Talent Project Funding of Zunyi city [No. 201423], as well as National First-Rate Construction Discipline of Guizhou Province (Pharmacy) [YLXKJS-YX-04] and the Fifth Batch of Talent Base in Guizhou Province (2016) is gratefully acknowledged.