Recent advancement in the synthesis of 1,2- and 2,1-benzothiazines

Abstract

1,2- and 2,1-benzothiazines, for example, 1,2-benzothiazine-1,1-dioxides. 2,benzothiazine-2,2-dioxides, 1-alkyl/aryl-1,2-/2,1-benzothiazine-S-oxides, dibenzothiazine and polyheterocycle containing benzothiazine moiety are considered to be one of the privileged heterocyclic scaffolds with huge importances both in synthetic organic chemistry and medicinal chemistry especially in the drug industry. Numerous pioneering methodologies for asymmetric and non-asymmetric scaffold constructions have been developed. Comprehensive visions of different powerful methodologies for the synthesis of these scaffolds have been presented in this review.

Graphical Abstract

Keywords:

• Cyclic sulfoximine
• dibenzothiazine
• metal catalyzed
• metal free synthesis
• heterocycle
• 1,2-benzothiazine
• 2,1-benzothiazine

Acknowledgments

The author is thankful to UGC and Department of chemistry, Santipur College, for facilities.