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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 24
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Articles

PEG-400 promoted a simple, efficient, and recyclable catalyst for the one-pot eco-friendly synthesis of functionalized isoxazole substituted pyrroles in aqueous medium

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Pages 3113-3122 | Received 27 Aug 2018, Published online: 19 Nov 2018
 

Abstract

A simple, efficient, and green approach for the synthesis of novel isoxazolyl pyrroles have been described by a one-pot reaction of isoxazolyl enamino esters and nitroolefins using H2O as a reaction medium and polyethylene glycol (PEG-400) as a promoter. This method demonstrates to be a simple, efficient, and environmentally benign in terms of metal, base free, less-reaction time, excellent yields, wide substrates scope, and PEG-400 can be recovered and reused. Most important of all, this reaction process is green.

GRAPHICAL ABSTRACT

Acknowledgments

RP thanks the Department of chemistry JNTU-H and Mylan Laboratories for providing research facilities. We are grateful to Dr. M. N. Reddy for his helpful discussions.

Additional information

Funding

This work was financially supported by the Department of Science and Technology (DST), New Delhi, for supporting this work [IFA13-CH-108 and Grant number GAP-0439].

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