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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 1
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Articles

Solventless Mechanosynthesis Of Bis(Indolyl)Methanes

, , , &
Pages 94-101 | Received 14 Aug 2018, Published online: 13 Jan 2019
 

Abstract

Ball-milling technique as a solvent-free and an alternative green process was investigated for the eco-benign synthesis of bis(indolyl)methanes (BIMs) from various aldehydes and selected ketones with indoles in high yields. The present methodology has several advantages such as simple procedure, good yields, mild conditions, and reduced environmental consequences. The silica gel acts both as a grinding medium and an acid catalyst. The utility of this technique was demonstrated by synthesizing library of 17 BIMs including two natural products trisindoline and tris(1H-indol-3-yl)methane.

Graphical Abstract

Acknowledgments

The authors thank Syngenta Bioscience, Goa for HRMS analysis.

Additional information

Funding

The authors are grateful to University Grants Commission (UGC), New Delhi for financial support.

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