Abstract
In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.
Graphical Abstract
![](/cms/asset/0e03ca07-7850-4a48-abaf-a48eb298f2b5/lsyc_a_1551548_uf0001_c.jpg)
Acknowledgments
We are grateful to the Federal University of São Carlos (UFSCar).