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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 7
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Articles

A practical and convenient Blanc-type chloromethylation catalyzed by zinc chloride under solvent-free conditions

Jian TangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, P. R. ChinaView further author information
,
Hongtao LiuCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, P. R. ChinaView further author information
,
Kailun HeCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, P. R. ChinaView further author information
&
Xingxian ZhangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, P. R. ChinaCorrespondence[email protected]
View further author information
Pages 925-932 | Received 05 Nov 2018, Published online: 08 Mar 2019
 
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Abstract

Chloromethylation of various aromatic hydrocarbons and substituted phenolic derivatives with dimethoxymethane and chlorosulfonic acid was carried out in the presence of 10 mol% of ZnCl2 in a mild and efficient manner under solvent-free conditions. In addition, 2,6-dimethyltyrosine was synthesized in high yield via this protocol.

GRAPHICAL ABSTRACT

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Funding

This work was supported by National Natural Science Foundation of China.

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