Abstract
An unprecedented ligand-free copper-catalyzed O-arylation of arenesulfonamides with phenols has been developed. Thus, a range of unsysmmetric biaryl ethers were synthesized in excellent yields. The reaction occurs efficiently with excellent regioselectivity through the cleavage of Cary-S bond and with a good tolerance of functional groups on the phenyl ring of phenols. The reaction is appreciated for its readily accessible substrates, mild conditions, and simple operation under air.
Graphical Abstract
![](/cms/asset/2a2a66a4-b251-423f-9761-1bdbaf489999/lsyc_a_1574833_uf0001_b.jpg)