An efficient and green protocol for synthesis of novel [1,3]oxazino[5,6-c]quinolin-5-one derivatives using [Et₃NH]HSO₄ as a reusable catalyst

Abstract

A simple, efficient, and eco-friendly procedure has been developed using acidic ionic liquid [Et₃NH]HSO₄ as catalyst for the synthesis of novel [1,3]oxazino[5,6-c]quinolin-5-one derivatives via one-pot three-component condensation reaction of 4-hydroxyquinolin-2(1H)-one, amine and formaldehyde in aqueous ethanol at room temperature. Mild and environmentally benign reaction conditions, short reaction time, good to excellent yields, nontoxic, cheap and easily available catalyst, reusability of catalyst and reaction media, and easy work-up are the key features of this method.

Graphical Abstract

Keywords:

• [1,3]Oxazino[5,6-c]quinolin-5-one
• [Et₃NH]HSO₄
• 4-hydroxyquinolin-2(1H)-one
• multicomponent reactions
• green chemistry

Additional information

Funding

The authors thank the Fundamental Research Funds for the Central Universities, South-Central University for Nationalities (CZP17006) for financial support.