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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 16
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Articles

A facile and efficient approach for the synthesis of 3-arylthiazol-2(3H)-one

Yue ZhuZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China; View further author information
,
Qilin WangSchool of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, P. R. ChinaView further author information
,
Haofan LuoZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China; View further author information
,
Zijuan WangZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China; View further author information
,
Guolin ZhangZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China; Correspondence[email protected]
View further author information
&
Yongping YuZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China; Correspondence[email protected]
View further author information
Pages 2066-2072 | Received 12 Feb 2019, Published online: 16 May 2019
 
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Abstract

A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80 °C at first and then in acidic condition at room temperature, to afford products in good yields for a wide range of substrates and a possible mechanism has also been proposed.

GRAPHICAL ABSTRACT

Additional information

Funding

This project was supported from Zhejiang Provincial Natural Science Foundation of China [LY16H300001] to G. Zhang; National Natural Science Foundation of China [No. 81673291 and 81473074], and Osteoporosis & Breast Cancer Research Center, U.S.A. to Y. Yu.

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