Abstract
A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and alkyne intermediates.
Graphical Abstract
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Acknowledgements
We thank Dr. Reddy’s Institute of Life Sciences for its support. We thank Mahesh Tammineni for his help in synthesis of compound 12.