A metal-free approach to access ketones, amides, and nitriles employing TBAI/TBHP oxidative system in water

Abstract

Hydrocarbons, benzylamines, and heteroaromatic-bearing amines have been efficiently employed as substrates in allylic and benzylic oxidations via C(sp3)–H bond activation by TBAI/TBHP in water. This operationally simple method allows access to ketones, nitriles, and amides in moderate to high yields and a regio- and chemoselective late-stage functionalization.

GRAPHICAL ABSTRACT

Keywords:

• Allylic oxidation
• benzylic oxidation
• in water
• metal-free oxidation

Additional information

Funding

We thank Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) for financial support [FAPESP 2017/18400-6]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001.