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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 24
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Synthetic Communications Reviews

Synthesis, characterization, and biological evaluation of indole aldehydes containing N-benzyl moiety

, , &
Pages 3486-3497 | Received 01 May 2019, Published online: 14 Oct 2019
 

Abstract

The present study describes the synthesis, characterization and biological evaluation of N-benzyl indole aldehydes. The biological activities of the newly synthesized compounds were examined by investigating their antioxidant and anti-inflammatory activities. The potential of these compounds as an antioxidant was determined by 2,2-diphenylpicrylhydrazyl, Nitric oxide, Superoxide, peroxide radical scavenging methods. We found that aldehydes 4a, 4b, 4c, and 4e and shows promising in vitro DPPH scavenging antioxidant activity while aldehyde 4b and 4e show good in vitro anti-inflammatory activity.

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Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Acknowledgments

Authors would like to thank Schrödinger Inc. for providing the Demo license of Schrödinger Molecular Modeling Suite and especially Craig Coel for his valuable support that has significantly helped in this study and Department of Chemistry, Rajaram College Kolhapur for providing necessary facility.

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