Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

Abstract

A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.

GRAPHICAL ABSTRACT

Keywords:

• α-amino amide
• isocyanides
• Ugi reaction

Acknowledgments

The authors acknowledge Lupin Research Park and Manipal Academy of Higher Education for providing the opportunity to take up this research work. Thankful to Lupin Research Park, R&D, Analytical team for supporting the analysis.