Abstract
A convenient synthetic route for the preparation of α-aminophosphonate derivatives of triethoxysilane, attractive precursors for silica surface functionalization, was developed. The condensation of commercially available APTES with carbonyl compounds followed by Pudovik reaction of imines with diethyl phosphite yielded desired N-phosphonomethyl functionalized (3-aminopropyl)triethoxysilanes in high yields without further purification. The chemical structures of obtained products were undoubtedly proved by 1H, 13C and 31P NMR spectroscopy, elemental analysis and mass spectrometry.
Graphical Abstract
Acknowledgments
We are grateful to V.I. Musatov (“Institute for Single Crystals” NAS of Ukraine, Kharkiv, Ukraine), Enamine Ltd. (Kiev, Ukraine) for spectroscopic measurements and Albina Mikhralieva (Rio de Janeiro, Brazil) for fruitful discussion.