Abstract
An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.
GRAPHICAL ABSTRACT
![](/cms/asset/0b85f4f5-99c3-4c01-b8a7-0749cca344c8/lsyc_a_1700521_uf0001_c.jpg)