PEG-400 assisted Kröhnke synthesis of 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C₅-C₆ cycles with substituted benzylidene group

Abstract

A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C₅-C₆ cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered using cross-conjugated dienones as substrates by counter synthesis.

Graphical Abstract

Keywords:

• Cross-conjugated dienones
• 2-(2-hydroxyphenyl)pyridines
• Kröhnke reaction
• PEG-400

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.