Metal-free and base-free decarboxylation of substituted cinnamic acids in a deep eutectic solvent

Abstract

A metal-free and base-free strategy was developed in DES to synthesize styrenes for the first time by decarboxylation of cinnamic acid derivatives, which provided a renewable and cost efficiently protocol to access various styrenes including those with functional groups such as 4-vinylphenol and 1-chloro-4-vinylbenzene.

GRAPHICAL ABSTRACT

Keywords:

• Base-free
• decarboxylation
• deep eutectic solvent
• metal-free
• substituted styrene

Notes

1 The reaction temperature is not corrected in this job, and it was 118 °C after corrected.

Additional information

Funding

This work was supported by the Key Research and Development Programs of Hunan Science and Technology Department (2018SK2113, 2018SK2119 and 2018WK2081), Administration of Traditional Chinese Medicine of Hunan Province scientific research project (2018-57), Pharmaceutical Open Fund of Domestic First-class Disciplines (cultivation) of Hunan Province (2018YX02) and Undergraduate research-based learning and innovative experimental project of Hunan University of Chinese Medicine (2018-43).