Facile synthesis and anti-proliferative activity evaluation of quinoxaline derivatives

Abstract

A series of “drug-like” compounds based on quinoxaline scaffold with arylsulfonyl hydrazinyl, arylformyl hydrazinyl or arylsulfonyl groups at C-2 and aryloxy groups at C-3, were synthesized in 4 or 5 steps involving cyclization, chlorination and coupling reactions. Cellular anti-proliferative activities of these quinoxaline derivatives in vitro were determined, which revealed that the inhibitory potency and selectivity of 6f was comparable to that of the positive control.

Graphical Abstract

Keywords:

• Arylformyl hydrazinyl
• arylsulfonyl
• 2-arylsulfonyl hydrazinyl-3-aryloxy quinoxaline
• antitumor activity
• synthesis

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

We appreciate the funds provided by Natural Science Foundation of Fujian Province [No. 2019J05073, 2018J01846], the Joint Funds for the Innovation of Science and Technology of Fujian Province [No. 2016Y9052, 2018Y9071], the Program for the High-Level Talents Introduction in Fujian Medical University [No. XRCZX2017010], the Program for the Distinguished Young Research Talents in Universities of Fujian Province [No. 2017B021] and the Program for the Middle-aged and Young Key Talents in Health System of Fujian Province [No. 2019-ZQN-69] for financial support.