Abstract
Two novel structural isomers: the dihalo-5,5-dimethyl-2-cyclohexenones were synthesized. Regioselective Suzuki-Miyaura cross coupling reaction of the isomers with nine different aryl boronic acids afforded eighteen novel compounds: the 2-aryl-3-chloro-5,5-dimethyl-2-cyclohexenones and the 3-aryl-2-chloro-5,5-dimethyl-2-cyclohexenones in 90–95% yields, which were characterized spectroscopically by IR, NMR and MS. The single crystal X-Ray diffraction ORTEP views of four representative compounds unambiguously confirm the formation of substituted cyclohexenones.
Graphical Abstract
Acknowledgments
The authors thank (1) JCAS for Council of Scientific and Industrial Research (CSIR), Govt. of India, New Delhi, INDIA; CSIR SRF – File no. 09/039(0119)/2018-EMR-1, dated April 16, 2018.; (2) Bengaluru Central University.; (3) Bangalore University and (4) Dr. B. S. Bandodkar, Pharmaron Chemical Company, Beijing, China for all help rendered; (5) Suman Bharadwaj, Christ University, Bangalore.; and (6) Avinash, R., Bangalore; Sreenatha, N. R., Hassan.