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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 7
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ARTICLES

Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst

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Pages 1056-1063 | Received 14 Nov 2019, Published online: 26 Feb 2020
 

Abstract

Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1 is easily available, cheap, and eco benign.

Graphical Abstract

Acknowledgments

The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities.

Additional information

Funding

The authors are thankful to University Grant Commission, New Delhi for Junior research fellowship (S.S), Department of Science and Technology, Government of India, New Delhi for INSPIRE fellowship (A.G) and NMR facility under PURSE.

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