PEG-assisted one-pot three-component synthesis of 1,3-oxazino quinoline and chromeno 1,3-oxazin derivatives under catalyst free condition

Abstract

A straightforward and greener PEG-assisted protocol has been disclosed for the cascade synthesis of [1,3]Oxazino quinoline, and chromeno[1,3]oxazin derivatives via three component reaction of multifarious aromatic amines with formaldehyde and 4-hydroxyquinoline-2(1H)-one or 4-methylumbelliferone by using very convenient reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity oriented highly pure [1,3]oxazino scaffolds with broad substrate scope.

Graphical Abstract

Keywords:

• Chromeno 1,3-oxazin
• multicomponent reactions (MCRs)
• [1,3]oxazino quinoline
• polyethylene glycol (PEG-600)

Additional information

Funding

This work was supported by a research grant of Pukyong National University (2019).