An efficient one-pot strategy for the synthesis of 4- methylene-2-thiazolidinethiones in water

Abstract

A simple and efficient, one-pot strategy for the preparation of 4-methylene-2-thiazolidinethiones has been developed. This protocol involved condensation of primary amines with carbon disulfide in water to generate the dithiocarbamate salts in situ, which coupled with 2,3-dibromopropene, followed by intramolecular cyclization to the corresponding heterocycles in moderate to good yields.

Graphical Abstract

Keywords:

• Carbon disulfide
• 2,3-dibromopropene
• 4-methylene-2-thiazolidinethiones
• one-pot procedure
• primary amines

Additional information

Funding

We are grateful to the National Natural Science Foundation of China [No. 21762022], the Research Program of Jiangxi Province Department of Education [No. GJJ160289, GJJ11380], the Opening Foundation of National Research Center for Carbohydrate Synthesis [No. GJDTZX-KF-201414], and the Opening Foundation of Key Laboratory of Functional Small Organic Molecule of Ministry of Education [No. KLFS-KF-201411] for the financial support.