Highly efficient synthesis of 1,2,4-thiadiazoles from thioamides utilizing tetra(n-butyl)ammonium peroxydisulfate

Abstract

A new synthetic approach to 1,2,4-thiadiazoles using tetra(n-butyl)ammonium peroxydisulfate via oxidative dimerization of thioamides is described. This new oxidative protocol is simple, highly efficient, and allows the practical synthesis of 1,2,4-thiadiazoles from various primary thioamides in good to excellent yields.

Graphical Abstract

Keywords:

• Oxidative dimerization
• primary thioamide
• tetra(n-butyl)ammonium peroxydisulfate
• 124-thiadiazole

Acknowledgments

The authors thank Woosuk University for supporting this work (2019).