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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 11
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SYNTHETIC COMMUNICATIONS REVIEWS

C7-Friedel–Crafts alkylation of 4-aminoindoles with para-quinone methide derivatives under catalyst-free conditions

, &
Pages 1679-1686 | Received 18 Feb 2020, Published online: 24 Apr 2020
 

Abstract

The first example of Friedel–Crafts alkylation of indoles with para-quinone methide derivatives at the C7 position was developed by using 4-alkylaminoindoles as nucleophiles under catalyst-free conditions. It is a mild and efficient protocol to access 7-indolyl-containing triarylmethane derivatives. This methodology features advantages including broad scope, operational simplicity, and the potential utility for the synthesis of biologically active compounds.

Graphical Abstract

Additional information

Funding

We thank the National Natural Science Foundation of China [Grant 21772199 and 21971264] for financial support of this program.

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