Synthesis of isoquinolinone derivatives by Rh (III)-catalyzed C–H functionalization of N-ethoxybenzamides

Abstract

An efficient Rh-(III)-catalyzed C-H functionalization of N-ethoxybenzamides with 1-alkynylcyclobutanols has been developed. Isoquinolone derivatives have been successfully synthesized through [4 + 2] annulation and ring opening reaction under mild conditions. The advantages of this efficient protocol include broad substrate scope and good to excellent yields.

Graphical Abstract

Keywords:

• 1-alkynylcyclobutanols
• isoquinolinone
• N-ethoxybenzamides
• rhodium

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (NSFC) [21676252 and 21506191].