Abstract
1,4-Dihydropyridines and 4H-pyran derivatives are common and important structures in various pharmaceutical compounds. Dihydropyridines are well-known moieties in compounds that have analgesic, fungicidal, and antibacterial activities and 4H-pyran structures are populous in compounds with antibacterial and anti-cancer potential; exploiting the biological activities of both 1,4-dihydropyridines and 4H-pyran moieties through the exploration of hybrid compounds featuring combinations of these two heterocyclic functionalities is an interesting avenue of research. In this research, we developed novel 1,4-dihydropyridines and 4H-pyran hybrid compounds generated under organocatalytic conditions and evaluated their cytotoxic activity toward KB and HepG2 cancer cell lines.