Metal-free synthesis of 2-mercaptobenzothiazoles and 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles via microwave-assisted synthesis pathway

Abstract

A simple, efficient, and metal-free methodology for the preparation of 2-mercaptobenzothiazole and derivatives in excellent yields via microwave-assisted pathway is reported. Our condition provides a convenient protocol for the synthesis of a diverse collection of 2-mercaptobenzothiazoles and 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles with a very simple purification process. This report provides an alternative protocol for fast access to the wide range of compounds for sequence synthesis and biological studies.

Graphical Abstract

Keywords:

• microwave-assisted synthesis
• metal-free
• 2-mercaptobenzothiazole

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supporting Information

Full experimental detail, characterization data of new compounds, ¹H and ¹³C NMR spectra. This material can be found via the “Supplementary Content” section of this article’s webpage.

Additional information

Funding

This research is funded by PHENIKAA University under grant number 01.2020.05.