A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones

Abstract

A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.

Graphical Abstract

Keywords:

• 4-Chloro-N-hydroxybenzimidoylchloride
• dihydroquinazolinones
• isatoic anhydride

Acknowledgements

The authors would like to thank Dr. Reddy’s Laboratory, Hyderabad for providing facilities to carry out this work. One of the authors Dr. Krishnaji acknowledges CHRIST (Deemed to be University) for funding Major Research Project (MRP # MRPDSC-1723).