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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 14
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SYNTHETIC COMMUNICATIONS REVIEWS

An efficient metal-free synthesis of carbodiimide-tethered amino acid conjugates

, , &
Pages 2171-2180 | Received 18 Mar 2020, Published online: 28 May 2020
 

Abstract

In this study, we report a straightforward oxidative cross-coupling synthesis of carbodiimide tethered amino acid conjugates from amino acid-derived isocyanides and aryl amines mediated by I2/tert-butyl hydroperoxide. Using this protocol, the title compounds were obtained in good isolated yields. This protocol is of short reaction duration, base-free, racemization free and avoids the necessity of transition metal catalysts.

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Additional information

Funding

We thank the Council of Scientific and Industrial Research (Grant No. 02(0352)/19/EMR-II), Govt. of India, for the financial assistance.

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