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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 14
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SYNTHETIC COMMUNICATIONS REVIEWS

An efficient and scalable approach for the synthesis of piperazine based glitazone and its derivatives

, &
Pages 2181-2187 | Received 14 Mar 2020, Published online: 27 May 2020
 

Abstract

A versatile and efficient synthetic approach has been developed for the synthesis of piperazine based glitazones analogous to Lobeglitazone. Desired compounds were synthesized with good yields by alkylation of piperazine substrate with various carbonyl compounds. This substrate has the potential for the construction of novel heterocyclic compounds with medicinal importance.

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Acknowledgments

We acknowledge Amity Institute of Applied Sciences, Amity University, Sector-125, Noida, Uttar Pradesh, India for the facilities extended during this work.

Additional information

Funding

We are highly grateful to Integral BioSciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida, Uttar Pradesh, India for financial and analytical support for this work.

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