Abstract
A versatile and efficient synthetic approach has been developed for the synthesis of piperazine based glitazones analogous to Lobeglitazone. Desired compounds were synthesized with good yields by alkylation of piperazine substrate with various carbonyl compounds. This substrate has the potential for the construction of novel heterocyclic compounds with medicinal importance.
Graphical Abstract
Acknowledgments
We acknowledge Amity Institute of Applied Sciences, Amity University, Sector-125, Noida, Uttar Pradesh, India for the facilities extended during this work.