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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 17
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Synthetic Communications Reviews

Synthetic strategies and functional reactivity of versatile thiophene synthons

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Pages 2590-2616 | Received 05 May 2020, Published online: 06 Jul 2020
 

Abstract

Thiophenes are a highly important group of heterocycles and have been of great interest to researchers due to their various reactivities. Many synthetic strategies are used to generate functionalized thiophene derivatives. Several reactions are described, depending on the reactivity of the substituents attached to the thiophene nucleus toward different nucleophiles to yield the versatile thiophene products. Many diverse applications have been utilized for thiophenes from medicinal chemistry to material science.

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