Double Schiff bases derivatives of chitosan by selective C-6 and C-2 oxidation mediated by 5-fluorosalicylaldehyde aniline by TG-GC-MS and TG-FTIR analysis

Abstract

This enhancement in the activity may be efficient on the basis that ligands mainly possess CH=N bond. The use of a structure-based drug design approach (SBDD) provides a way for investigation as well as to understand the molecular basis of the target protein and ligand molecule interactions at the atomic level. Structure-based drug design is the design and optimization of a chemical structure to identify a compound suitable for clinical testing the drug candidates. Chitosan is a polysaccharide with recognized biological activities for improving the functionality of polysaccharide 5-Fluorosalicylaldehyde aniline system. The used for selectively oxidized chitosan to produce tailored derivatives. C-2-5-Fluorosalicylaldehyde-C-6 aniline double Schiff base derivatives of chitosan were synthesized. The structure and properties of the newly synthesized product were characterized by FT-IR, ¹H-NMR, ¹³C-NMR, GC-Mass spectroscopy, and thermal analysis (DSC/TGA). An exothermic process discusses a DSC and TGA analysis of thermal behavior of this polymer was shown to be a possible thermal polymerization of the double bonds in the polymer chains and thermo-oxidation of the polymer.

Graphical Abstract

Keywords:

• Cross-linking
• oxidation
• soluble chitosan
• thermal polymerization
• TG-GC-MS
• TG-FTIR

Acknowledgments

Authors would like to thank Sophisticated Analytical Instrument Facility (SAIF) IIT Madras for their FT-IR, GC-Mass, ¹H-NMR spectral studies, and thermal analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).