Abstract
The asymmetric α-hydroxylation of β-dicarbonyl compounds was catalyzed by C-2′-modified cinchonine-derived phase-transfer catalysts. Excellent yields (up to 95%) and good enantioselectivities (up to 89% ee) were obtained. The reaction was carried out in a flow microreactor and similar results were obtained (up to 93% yield, 84% ee), the residence time was shortened from 24 h in batch to 2 h.
Graphical Abstract
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