Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 19
170
Views
1
CrossRef citations to date
0
Altmetric
Articles

One-pot sequential synthesis of quinazolin-8-ol derivatives employing heterogeneous catalyst for Suzuki–Miyaura coupling

, &
Pages 2962-2968 | Received 26 Apr 2020, Published online: 05 Jul 2020
 

Abstract

We report herein an efficient and eco-friendly method for a one-pot sequential synthesis of quinazolin-8-ol derivatives. A variety of boronic acids were used for Suzuki–Miyaura coupling with commercially available SiliaCat ® DPP-Pd heterogeneous catalyst. Use of this catalyst ensures minimal leaching of palladium in the product and alleviates the need of further purification. The reaction conditions used in the four synthetic steps were optimized to telescope three intermediates without first requiring their isolation to establish an efficient and eco-friendly one-pot synthesis.

Graphical Abstract

Acknowledgment

We are highly grateful to Integral BioSciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida, Uttar Pradesh, India for financial and analytical support for this work. We also acknowledge Amity Institute of Applied Sciences, Amity University, Sector-125, Noida, Uttar Pradesh, India for the facilities extended during the course of this work.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.