Unprecedented total synthesis of bruceolline D, E, and H

Abstract

Single pot strategy of wittig olefination-Claisen rearrangement has been employed to obtain 3-prenylated indoles. The resulting indoles on the consecutive sequence of epoxidation, cyclization and further oxidation afforded short, protecting group free total synthesis of bruceolline D, E and H.

Graphical Abstract

Keywords:

• Claisen rearrangement
• consecutive sequence
• 3-prenyl indole
• wittig olefination

Acknowledgments

Author thanks Central Instrumentation Facility, Savitribai Phule Pune University, Pune and SAIF, Punjab University, Chandigarh for spectral analysis. He is grateful to the Principal, Dr. R. J. Barnabas, Ahmednagar College, Ahmednagar for providing all necessary lab facility.

Disclosure statement

No potential conflict of interest was reported by the author(s).