Abstract
Novel 2,3,4,9-tetrahydro- and 4,9-dihydro-1H-benzo[f]isoindole derivatives were synthesized from Juglone and amino-acid azomethines in 74–85% yields via 1,3-dipolar cycloaddition. The stereo- and regioselectivity of cycloaddition was confirmed by NMR spectra and single-crystal X-ray diffraction analysis.
Graphical Abstract
Supplementary information
Supplementary data (spectral and analytical data for compounds 3a,b and 4) associated with this article can be found, in the online version, at http://dx.doi.org/10.1080/00397911.2020.1795880.
Acknowledgments
We would like to express the warmest appreciation to Erasmus + program aims to support actions in the fields of Education, Training, Youth and Sport for the period 2014–2020 and to Professor Arnaud Martel (Le Mans University, France) for support and assistance in conducting research.