A simple and efficient approach for the preparation of dihydroxanthyletin, xanthyletin, decursinol and marmesin

Abstract

A simple and efficient approach has been developed for the preparation of coumarin natural products such as dihydroxanthyletin, xanthyletin, decursinol and marmesin starting from commercially available 2,4-dihydroxybenzaldehyde with very good yields. Wittig homologation and Claisen rearrangement are the protocols used to achieve these molecules.

Graphical Abstract

Keywords:

• Claisen rearrangement
• 2,4-dihydroxybenzaldehyde
• natural products
• Wittig homologation

Acknowledgments

The authors are thankful to the Director, CSIR-IICT (Communication no: IICT/Pubs./2019/406) for providing the required facilities to carry out the research work.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

B. China Raju acknowledges SERB (DST), India, for the financial support (EEQ/2017/000314). KRK acknowledges CSIR, India, for the award of fellowship.