Nickel complexes as efficient catalysts in multicomponent synthesis of tetrahydropyridine derivatives

Abstract

Ni(Salen) complexes as an efficient, homogeneous catalysts revealed a catalytic activity toward the one-pot synthesis of tetrahydropyridine derivatives through the pseudo five-component reactions of aromatic aldehydes, aromatic amines, and β-ketoesters in ethanol at room temperature. Mild reaction conditions, good yields, high diastereoseletivity, operational simplicity, and the absence of tedious separation procedures, clean reaction profiles, high atom economy, inexpensive starting materials, and environmentally benign catalyst are the key advantages of the present MCRs protocol.

Graphical Abstract

Keywords:

• Heterocycles
• Lewis acids
• nickel complexes
• one-pot synthesis
• tetrahydropyridines

Acknowledgments

Scientific research was performed at the Research Parks of St. Petersburg State University “Center for Chemical Analysis and Materials Research” and “Educational Resource Center of Chemistry.”