Abstract
Thiazole derivatives represent an important class of azole heterocycles with a broad spectrum of biological activity and, therefore, the synthesis of these compounds is of remarkable concern. We present here practical and reliable protocol for synthesis of some 5-acylthiazoles and demonstrate their utility in the preparation of several new series of thiazole-containing building blocks through transformation of 5-acyl function. Specifically, thiazole-based alcohols, oximes, primary, and secondary amines were successively synthesized in good to excellent yields. The chemical structures of obtained compounds were confirmed by 1H and 13C NMR-spectroscopy, elemental analysis, and mass-spectrometry.
Graphical Abstract
Acknowledgments
The authors thank V. I. Musatov, E. V. Vashchenko (STC “Institute for Single Crystals” NAS of Ukraine, Kharkiv, Ukraine), and A. V. Borisov (Enamine Ltd., Kiev, Ukraine) for spectroscopic measurements.