Abstract
A simple and straightforward protocol has been accomplished for synthesis of pyrazolo[3,4-b]pyridines by reacting 5-amino-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (1) and β-enaminoketones (2) promoted by Iron(III)chloride. This protocol was also able to produce quinolines (5) by the reaction of O-nitrobenzaldehydes and β-enaminoketones. Simple reaction conditions, high compatibility and excellent yields are the advantages of this protocol.
Graphical Abstract
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Acknowledgements
We gratefully acknowledge the help received from centre for NMR & Structural Chemistry and Analytical Chemistry & Mass Spectrometry, CSIR–IICT. We thank director CSIR-IICT for the support (IICT/pubs./2019/407).