Biologically active tetrazole scaffolds: Catalysis in magnetic nanocomposites

Abstract

Tetrazoles are an important class of nitrogen-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Recent literature studies clearly showed that tetrazoles have a broad spectrum of biological and pharmacological activities such as antiallergic, antiinflammatory, antiulcer, antibiotic, antihypertensive, antineoplastic, antiviral and receptor modulator activities. Magnetic recoverable nanocatalysts can be readily separated from reaction medium by using an external magnet, without the need for filtration, centrifugation or other tedious workup processes. In recent times, the catalytic potential of magnetically recoverable nanocatalysts was evaluated in synthesis of biologically active tetrazole derivatives. In this review, we focused on the fabrication, surface modification and characterization of nanomagnetite materials and their application as magnetically recoverable catalysts in the synthesis of biologically active tetrazole structural scaffolds.

Graphical Abstract

Keywords:

• Easy separation
• medicinal chemistry
• nanomagnetic catalysts
• tetrazole scaffolds