Abstract
An expedient one-pot sequential five component synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles involving [3 + 2]-cycloaddition of azomethine ylides as the key step is described. The protocol provides a mild reaction condition, high yield of the products, high regioselectivity and operational simplicity to assemble complex structural entity in a single operation. The structure of the product was confirmed by spectroscopic techniques and elemental analysis.
Graphical Abstract
Acknowledgements
DG thanks Vels University for the support and encouragement. ARS thanks University Grants Commission (UGC) for the start-up grant under UGC-Faculty Recharge Programme.