A facile atom – economical synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles via a sequential multicomponent reaction

Abstract

An expedient one-pot sequential five component synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles involving [3 + 2]-cycloaddition of azomethine ylides as the key step is described. The protocol provides a mild reaction condition, high yield of the products, high regioselectivity and operational simplicity to assemble complex structural entity in a single operation. The structure of the product was confirmed by spectroscopic techniques and elemental analysis.

Graphical Abstract

Keywords:

• Multicomponent reaction (MCR)
• polyheterocycles
• azomethine ylide
• quinoxaline
• pyrazole
• N-methylpiperidine
• spiro-pyrrolidines

Acknowledgements

DG thanks Vels University for the support and encouragement. ARS thanks University Grants Commission (UGC) for the start-up grant under UGC-Faculty Recharge Programme.

Additional information

Funding

One of the author ARS thanks University Grants Commission (UGC) for the start-up grant under UGC-Faculty Recharge Programme.