One-pot three-component synthesis of isoxazole using ZSM-5 as a heterogeneous catalyst

Abstract

A mild and convenient route for the synthesis of isoxazole derivatives has been developed using ZSM-5 as a heterogeneous catalyst. The reaction was carried out under a solvent-free condition to afford the desired products in good yields. A variety of functional groups was tolerated under the reaction conditions employed. Moreover, the heterogeneous catalyst (ZSM-5) was recovered and reused several times without significant loss of its catalytic activity.

Graphical Abstract

Keywords:

• Aldehydes
• one pot
• isoxazole
• ZSM-5
• ethyl acetoacetate