Abstract
A simple, efficient, cost-effective and one-pot eco-friendly protocol has been developed for the synthesis of new isoxazolyl-4-hydroxyindole-3-carboxylate derivatives by using 4-amino-3-methyl-5-styrylisoxazoles, 2,3-diketoesters and 1,3-cyclohexanediones, in the presence of p-toluenesulfonic acid (p-TSA) catalyst in aqueous medium. The advantages of this protocol are inexpensive catalyst, metal-free, shorter reaction time, environmentally friendly, high yields, water as a solvent, wide substrates scope and easy purification.
GRAPHICAL ABSTRACT
![](/cms/asset/b88572d0-2e6b-4a3c-9479-49ba060d16d3/lsyc_a_1825743_uf0001_b.jpg)
Acknowledgments
Vanaja Rani thanks the Department of Chemistry Koneru Lakshmaiah Education Foundation for providing research facilities. We are grateful to Prof. Ravindhranath and Dr. NAGI REDDY for their valuable support and discussions.
Disclosure statement
No potential conflict of interest was reported by the author(s).