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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 24
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Articles

Synthesis of N-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs

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Pages 3845-3853 | Received 28 Aug 2020, Published online: 09 Oct 2020
 

Abstract

Syntheses of pyridazine derivatives of dibenzoazepine, starting from N-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence, N-substitute dibenzoazepine derivatives were synthesized and then, examined inverse electron demand Diels–Alder (IEDDA) reactions between N-substituted dibenzoazepine derivatives and tetrazines. While in some reactions, targeted products were obtained using phenyliodo-bis(trifluoroacetate) (PIFA), in other reactions, they were obtained directly with tetrazines which also behaved as the oxidizing agent. Structures of these compounds were fully characterized by NMR, IR, and HRMS spectroscopic techniques.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors are grateful to Atatürk University for financial support.

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