Acetic acid promoted an efficient and eco-friendly one-pot synthesis of functionalized novel isoxazolyl amino chromenopyrrole derivatives in aqueous medium

Abstract

An efficient, economical, and environmentally friendly method has been reported for one-pot synthesis of isoxazolyl amino chromenopyrrole derivatives from 4-amino-3-methyl-5-styrylisoxazoles, aryl glyoxal monohydrates and 4-aminocoumarins by using acetic acid (AcOH) as a green promoter and water as a reaction medium under heating condition. The attractive features of this method are operational simplicity, environmentally friendly, metal-free, shorter reaction time, broad substrate scope, easy purification of products and good to excellent yields. Most important of all, this one-pot method is green.

Graphical Abstract

Keywords:

• AcOH
• green chemistry
• isoxazolylamino chromenopyrrole
• one-pot reaction
• water

Acknowledgments

Vanaja Rani thanks the Department of Chemistry Koneru Lakshmaiah Education Foundation for providing research facilities. We are grateful to Prof. K. Ravindhranath and Dr. Nagi Reddy Modugu for their valuable support and discussions.

Disclosure statement

No potential conflict of interest was reported by the author(s).