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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 4
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Articles

A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

Kangsheng Xuea College of Pharmacy, Changchun University of Chinese Medicine, Changchun, P. R. ChinaView further author information
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Guoxiang Sunb School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu, P. R. ChinaView further author information
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Yanzhi Zhangc College of Pharmacy, Dali University, Dali, P. R. ChinaView further author information
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Xubing Chenc College of Pharmacy, Dali University, Dali, P. R. ChinaView further author information
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Yang Zhoud Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information
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Jinjun Houd Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information
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Huali Longd Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information
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Zijia Zhangd Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information
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Min Leid Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaCorrespondence[email protected] [email protected]
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Wanying Wud Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;e University of Chinese Academy of Sciences, Beijing, P. R. ChinaCorrespondence[email protected] [email protected]
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Pages 625-634 | Received 24 Dec 2019, Published online: 20 Nov 2020
 
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Abstract

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

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Additional information

Funding

This work was supported by the Special Fund for Strategic Pilot Technology of the Chinese Academy of Sciences [XDA12020379], the National Natural Science Foundation of China [Grant 81973455], and the National Key R&D Program of China [2018YFC1707900].

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