Copper catalyzed C–O bond formation by direct C–H activation of THF with phenols: an approach to the synthesis of phenyl tetrahydrofuranyl ethers

Abstract

A direct oxidative transformation of phenol derivatives to the corresponding tetrahydrofuranyl ethers via C–H bond activation, in the presence of copper catalyst and desired products were achieved in good yields using TBHP as an oxidant.

GRAPHICAL ABSTRACT

Keywords:

• C–H activation
• Cu(OAc)₂
• phenol substrates
• tetrahydrofuranyl ethers

Acknowledgements

We thank Department of Chemistry, GITAM Deemed to be University, Hyderabad Campus, India, for providing space and instrumental support.