Abstract
The application of DMSO as an ideal source of carbon is highly attractive. A simple and novel protocol has been developed for the synthesis of phenolic compounds via CuSO4·5H2O-catalyzed cyclization of 1,3-dicarbonyl compounds with DMSO. It was found that the unsymmetrical 1,3-dicarbonyl compounds always gave a mixture of two isomeric products. In addition, the deuterium-labeling experiments revealed that the C2 in benzene rings resulted from DMSO.
Graphical Abstract
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