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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 11
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Articles

Activation of phenolic oxygen atom using polyphosphoric acid: Synthesis of carbonyl-containing dihydrobenzofurans/dihydrobenzopyrans

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Pages 1723-1730 | Received 25 Jan 2021, Published online: 01 Apr 2021
 

Abstract

Carbonyl-containing dihydrobenzofurans/dihydrobenzopyrans were prepared from carbonyl-containing ortho-allyl/prenylphenols by activation of phenolic oxygen atom using polyphosphoric acid (PPA). Various substrates were investigated, and the corresponding dihydrobenzofurans/dihydrobenzopyrans were obtained in good to excellent yields.

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Acknowledgments

The authors are grateful for the staff at the Key Laboratory of Chemistry for Natural Products of Guizhou Province and the Chinese Academy of Sciences.

Additional information

Funding

The work here was supported by the National Natural Science Foundation of China [No. 81860609], the Guizhou Provincial Natural Science Foundation [No. QKHJC[2019]1213], the High-level Innovative Talents Training in Guizhou Province [No. 2015-4027], the Project of Guizhou Science and Technology Platform and Talent Team Under Grant [No. QKHPTRC[2017]5614], and the Plan Project of Science and Technology in Guizhou Province [No. QKHFQ[2020]4013].

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